First pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner: validation against microspheres
نویسندگان
چکیده
Background Animal models are important to develop our understanding of the pathophysiology of cardiovascular disease and for the development of new therapies. While coronary autoregulation maintains resting myocardial blood flow (MBF) constant over a wide range of pathological conditions, MBF reserve during hyperaemic stress is impaired in several common disease processes. First pass contrast-enhanced myocardial perfusion is the standard CMR method for the estimation of MBF and MBF reserve in man, but is challenging in rodents because of the constraints related to the high temporal and spatial resolution requirements. Murine first pass myocardial perfusion at rest can be performed on a whole-body 3 Tesla CMR system. Hyperaemic myocardial stress perfusion CMR in mice has however not been reported.
منابع مشابه
Hyperemic stress myocardial perfusion cardiovascular magnetic resonance in mice at 3 Tesla: initial experience and validation against microspheres
BACKGROUND Dynamic first pass contrast-enhanced myocardial perfusion is the standard CMR method for the estimation of myocardial blood flow (MBF) and MBF reserve in man, but it is challenging in rodents because of the high temporal and spatial resolution requirements. Hyperemic first pass myocardial perfusion CMR during vasodilator stress in mice has not been reported. METHODS Five C57BL/6 J ...
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A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans. (2012). A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans. General rights Copyright ...
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